The 10C update for Windows Server 2016 has just been published, it includes critical updates for Storage Spaces Direct deployments and we recommend all customers aggressively adopt. This update addresses all top known supportability issues.
October 18, 2018—KB4462928 (OS Build 14393.2580)
Specifically, this update includes fixes for the following issues:
"Event 5120" with STATUS_IO_TIMEOUT c00000b5 after an S2D node restart on Windows Server 2016 May 2018 update or later
Virtual Disks resources are in No Redundancy or Detached status in a Storage Spaces Direct cluster